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Description:Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo Title: Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population. Matrix-Gla protein promotes osteosarcoma lung metastasis and associates with poor prognosis. Also, that GCF MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation.