Reduced water penetrates nerves



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Summary: The entry of anti-infectives into the central nervous system (CNS) . of water or solutes can occur between brain capillaries, CSF, and nervous tissue: .. Although the penetration of large hydrophilic compounds into the CSF is low, .

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Chapter 7 - Lower cranial nerve function


Chapter 7: Lower cranial nerves

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best of Nerves penetrates Reduced water

Reduced water penetrates nerves

Chapter 7: Lower cranial nerves

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Reduced water penetrates nerves

Description:The x-axis represents blood sampling time after dosing. BBB microvascular changes such as increased number of fragmented vessels with fewer intact branches, atrophic string vessels, and increased irregularity of capillary surfaces have been described in AD Zlokovic, Because BBB permeability of leukocytes and large molecules such as peripheral IgG is enhanced, it is reasonable to hypothesize that therapeutic agents, especially small molecules mol. Compounds with good potency and developability but with poor brain penetration are usually discarded during neurodegenerative drug discovery. The potential increased brain penetration of therapeutic agents in diseases could be very valuable for CNS drug discovery because usually discarded compounds could have been saved for progression. In this article, we have compared brain penetration of eight small molecules in AD and MS disease models and naive control animals.

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Views: 7400 Date: 2018-02-10 Favorited: 69 favorites

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