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Description:During childhood, many developmental changes occur, which influence both drug exposure and drug response 3. A three-compartment model for amoxicillin and a two-compartment model for clavulanic acid best described the data, in which allometric weight scaling and maturation functions were added a priori to scale for size and age. Current published dosing regimens result in subtherapeutic concentrations in the early period of sepsis due to augmented renal clearance, which risks clinical failure in critically ill children, and therefore need to be updated. All clearance parameters were scaled a priori using an allometric weight WT approach with a fixed exponent of 0. Drug and biochemical assays. Antimicrob Agents Chemother For the first 24 patients, only the amoxicillin compound was quantified.

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Views: 7752 Date: 2018-05-17 Favorited: 50 favorites

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