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What is a gene mutation and how do mutations occur? - Genetics Home Reference

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Gene mutations can be classified in two major ways: Hereditary mutations are inherited from a parent and are present throughout a person's life in virtually every cell in the body. These mutations are also called germline mutations because they are present in the parent's egg or sperm cells, which are also called germ cells. 14 Dec The study has important medical implications for predicting the risk of a second child inheriting a disease-causing mutation from its parents.

It also shows that developing sperm and egg cells undergo the same mutational processes as cancer cells, which may help researchers understand the origin of some.

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Description:Our editors will review what you've submitted, and if it meets our criteria, we'll add it to the article. Because there are seven age groups, there are 13 parameters: Sharing of these signatures between cancers and germ cells indicates that fundamental cellular processes that operate in cancers also operate in germ cells, and may help researchers understand the origin of some cancer causing mutations. In mice, a significant increase in the overall male germ cell mutation frequency as measured by the lacI assay was observed between 15 and 28 months of age The mean of the measured counts for the donors in a given age group i, when divided by ,, represents the proportion P M i of all sperm in age group i that are mutant. For more information about mutations:

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